IKBKG Antibody - middle region : Biotin (ARP30005_T100-Biotin)

Product Specifications

Gene Name

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Gene Aliases

IP, IP1, IP2, FIP3, IKKG, IPD2, NEMO, FIP-3, Fip3p, IMD33, AMCBX1, EDAID1, IKKAP1, ZC2HC9, IKK-gamma

Gene ID

8517

Swiss Prot

Q9Y6K9

Accession Number

NP_003630

Host

Rabbit

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human IKBKG

Target

Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males . In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito

Partner Proteins

CHUK; IKBKB; ATM; PIAS4; MALT1; TRIM13; BCL10; SUMO1; UBC; TRAF6; MTOR; RPTOR; RELA; NFKBIA; IKBKG; ARHGDIA; RHOA; CDC37; SRC; FYN; FKBP5; FGR; PPP4C; PPP2R1B; LYN; NMRAL1; USP7; ZC3H12A; IRAK1; USP10; RIPK1; SQSTM1; RNF31; PPP1CC; HDLBP; PPFIA1; PSMB8; K

Clonality

Polyclonal

Conjugation

Biotin

Type

Polyclonal Antibody

Applications

Sample Type

IKBKG is strongly supported by BioGPS gene expression data to be expressed in HepG2

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 86%; Rabbit: 100%; Rat: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer.

Reconstitution

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.