IKBKG Antibody - middle region: FITC (ARP30005_T100-FITC)

Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males . In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation. Familial incontinentia pigmenti is caused by mutations in the NEMO gene and is here referred to as IP2, or 'classical' incontinentia pigmenti. Sporadic incontinentia pigmenti, the so-called IP1, which maps to Xp11, is categorized as hypomelanosis of Ito

CHUK; IKBKB; ATM; PIAS4; MALT1; TRIM13; BCL10; SUMO1; UBC; TRAF6; MTOR; RPTOR; RELA; NFKBIA; IKBKG; ARHGDIA; RHOA; CDC37; SRC; FYN; FKBP5; FGR; PPP4C; PPP2R1B; LYN; NMRAL1; USP7; ZC3H12A; IRAK1; USP10; RIPK1; SQSTM1; RNF31; PPP1CC; HDLBP; PPFIA1; PSMB8; K

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.