Anti-Hu Myeloperoxidase PE-Cy™7

*Locke M, Francis RJ, Tsaousi E, Longstaff C: Fibrinogen protects neutrophils from the cytotoxic effects of histones and delays neutrophil extracellular trap formation induced by ionomycin. Sci Rep. 2020 Jul 16;10 (1) :11694., URL: https://pubmed.ncbi.nlm.nih.gov/32678135/

*Ximenes VF, Maghzal GJ, Turner R, Kato Y, Winterbourn CC, Kettle AJ: Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione. Biochem J. 2009 Dec 14;425 (1) :285-93., URL: https://www.ncbi.nlm.nih.gov/pubmed/19828014, *Hansson M, Olsson I, Nauseef WM: Biosynthesis, processing, and sorting of human myeloperoxidase. Arch Biochem Biophys. 2006 Jan 15;445 (2) :214-24., URL: https://www.ncbi.nlm.nih.gov/pubmed/16183032, *Ximenes VF, Silva SO, Rodrigues MR, Catalani LH, Maghzal GJ, Kettle AJ, Campa A: Superoxide-dependent oxidation of melatonin by myeloperoxidase. J Biol Chem. 2005 Nov 18;280 (46) :38160-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/16148002, *Chooklin S, Pereyaslov A, Bihalskyy I: Pathogenic role of myeloperoxidase in acute pancreatitis. Hepatobiliary Pancreat Dis Int. 2009 Dec;8 (6) :627-31., URL: https://www.ncbi.nlm.nih.gov/pubmed/20007081, *Murphy EJ, Maréchal A, Segal AW, Rich PR: CO binding and ligand discrimination in human myeloperoxidase. Biochemistry. 2010 Mar 16;49 (10) :2150-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/20146436

The mouse monoclonal antibody MPO421-8B2 recognizes human myeloperoxidase, a heme protein present in intracellular granules of myeloblasts, neutrophils and monocytes. It is a marker of acute myelogenous leukemias and acute lymphoblastic leukemias.