Anti-Hu IgE HRP
Immunoglobulin E (IgE) is a 180 kDa soluble protein serving as an antigen-specific unit of mast cell effector mechanisms. IgE has the lowest serum concentration of all immunoglobulins (approximately 0.5 mg/l) in healthy individuals, but upon allergen challenge its concentration in blood increases dramatically. Although biological survival of free IgE is very short (T1/2 = 2 days), it is stabilized after binding to its high affinity receptor. Unlike IgM- IgG- and IgA-committed B cells, IgE-switched B cells do not undergo clonal expansion.
Product Specifications
Certification
RUO
Immunogen
Purified human IgE.
Target Antigen
IgE
Clone
BE5
Applications
ELISA (QC tested)
Concentration
0.2 mg/mL
Format
HRP
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 0.01% thimerosal
References & Citations
Other References
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The antibody BE5 reacts with human IgE; it recognizes an epitope different from the ones recognized by 4G7.325 and 4H10 antibodies to IgE.
Species
Human
Isotype
Mouse IgG1
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