What is the catalog number for Anti-Ikaros FITC?

The catalog number for Anti-Ikaros FITC is 1F-159-T100.

What sizes are available for Anti-Ikaros FITC?

Anti-Ikaros FITC is available in the following size(s): 100 Tests.

Is Anti-Ikaros FITC in stock?

Anti-Ikaros FITC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Ikaros FITC?

Anti-Ikaros FITC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Ikaros FITC?

Estimated delivery time for Anti-Ikaros FITC is approximately 10 business day(s), depending on your location.

Anti-Ikaros FITC

Ikaros, also known as IKZF1 (Ikaros family zinc finger protein 1) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Helios. Ikaros forms homo- and heterodimers with these proteins and functions predominantly in early hematopoietic development. Expression of Ikaros, Aiolos and Helios is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Disruption of Ikaros leads to T and B cell leukemias.

Product Specifications

Certification

RUO

Reactivity

Mouse, Human

Immunogen

Recombinant human Ikaros (C-terminal part)

Target Antigen

Ikaros

Clone

4E9

Applications

FC-IC (QC tested)

Format

FITC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*López-Nieva P, Santos J, Fernández-Piqueras J: Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas. Carcinogenesis. 2004 Jul;25 (7) :1299-304. , URL: http://www.ncbi.nlm.nih.gov/pubmed/14976135 , *Loeper S, Asa SL, Ezzat S: Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. Cancer Res. 2008 May 15;68 (10) :3715-23., URL: http://www.ncbi.nlm.nih.gov/pubmed/18483254 , *Kathrein KL, Lorenz R, Innes AM, Griffiths E, Winandy S: Ikaros induces quiescence and T-cell differentiation in a leukemia cell line. Mol Cell Biol. 2005 Mar;25 (5) :1645-54., URL: https://pubmed.ncbi.nlm.nih.gov/15713624/, *Schwickert TA, Tagoh H, Gültekin S, Dakic A, Axelsson E, Minnich M, Ebert A, Werner B, Roth M, Cimmino L, Dickins RA, Zuber J, Jaritz M, Busslinger M: Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol. 2014 Mar;15 (3) :283-93., URL: http://www.ncbi.nlm.nih.gov/pubmed/24509509 , *Elliott J, Jolicoeur C, Ramamurthy V, Cayouette M: Ikaros confers early temporal competence to mouse retinal progenitor cells. Neuron. 2008 Oct 9;60 (1) :26-39., URL: http://www.ncbi.nlm.nih.gov/pubmed/18940586 , *Koipally J, Heller EJ, Seavitt JR, Georgopoulos K: Unconventional potentiation of gene expression by Ikaros. J Biol Chem. 2002 Apr 12;277 (15) :13007-15., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=koipally+j+heller+ej

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 4E9 recognizes Ikaros, a transcription factor (intracellular antigen) expressed broadly in hematopoietic progenitors and serving as a key regulator of lymphopoiesis.