Anti-A2aR Purified
Adenosine A2a receptor (A2aR) is expressed mainly in the brain, heart and on cells of the immune system. Its ligand, extracellular adenonosine, is generated in local tissues under hypoxic, ischemic or inflammatory conditions, and can lead to increased A2aR expression. This receptor has neuromodulatory functions, affects cardiac rhythm, cerebral and renal blood flow, sleep, neurodegenerative disorders, and is involved also in pain regulation. It is a novel therapeutic target for depression. In human and murine monocytes and macrophages A2aR modulates the production of inflammatory cytokines.
Product Specifications
Certification
RUO
Immunogen
Recombinant full length human A2aR
Target Antigen
A2aR
Clone
7F6-G5-A2
Applications
WB (reported), ICC (reported), FC-IC (QC tested), IHC-F (reported), IHC-P (reported)
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml. Intracellular staining.
Species
Rabbit, Dog, Mouse, Rat, Human, Sheep, Guinea pig
Isotype
Mouse IgG2a
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