Leteprinim

Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species[1][2][3][4].

Product Specifications

CAS Number

[138117-50-7]

Product Name Alternative

AIT-082 (free acid)

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/leteprinim.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=C(NC(CCN2C=NC3=C2NC=NC3=O)=O)C=C1

Molecular Formula

C15H13N5O4

Molecular Weight

327.29

References & Citations

[1]Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169 (2) :392-9.|[2]Lahiri DK, et al. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Ann N Y Acad Sci. 2000 Apr;903:387-93.|[3]Glasky AJ, et al. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol Biochem Behav. 1994 Feb;47 (2) :325-9.|[4]Gencpınar P, et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci Lett. 2011 Nov 14;505 (2) :205-10.