Prednisolone (disodium phosphate)

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Prednisolone disodium phosphate can be rapidly and completely hydrolyzed to Prednisolone in the plasma[1][2][3][4][5].

Product Specifications

CAS Number

[125-02-0]

Product Name Alternative

Prednisolone 21-phosphate disodium

UNSPSC

12352211

Hazard Statement

H361, H373

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/prednisolone-disodium-phosphate.html

Purity

99.5

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

C[C@@]1([C@@]2(O)C(COP(O[Na])(O[Na])=O)=O)[C@](CC2)([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@@H](O)C1

Molecular Formula

C21H27Na2O8P

Molecular Weight

484.39

Precautions

H361, H373

References & Citations

[1]Lambrou, G.I., et al., Prednisolone exerts late mitogenic and biphasic effects on resistant acute lymphoblastic leukemia cells: Relation to early gene expression. Leuk Res, 2009. 33 (12) : p. 1684-95.|[2]http://en.wikipedia.org/wiki/Prednisolone|[3]Mooren FC, et al. Influence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cell monolayers. Pharm Res. 1998 Jan;15 (1) :58-65.|[4]Musson DG, et al. Comparative corneal penetration of prednisolone sodium phosphate and prednisolone acetate in NZW rabbits. J Ocul Pharmacol. 1991 Summer;7 (2) :175-82.|[5]Boudinot FD, et al. Dose-dependent pharmacokinetics of prednisolone in normal and adrenalectomized rats. J Pharmacokinet Biopharm. 1986 Oct;14 (5) :453-67.