Antipain
Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) -induced transformation and increases chromosomal aberrations. Antipain restricts uterine DNA synthesis and function in mice[1][2][3][4].
Product Specifications
CAS Number
37691-11-5
UNSPSC
12352005
Hazard Statement
H302
Target
DNA/RNA Synthesis; Ser/Thr Protease
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/antipain.html
Solubility
10 mM in DMSO
Smiles
OC([C@@H](NC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NC(C([H])=O)CCCNC(N)=N)=O)=O)=O)CC1=CC=CC=C1)=O
Molecular Formula
C27H44N10O6
Molecular Weight
604.70
Precautions
P264-P270-P330-P501
References & Citations
[1]DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77 (11) :6649-53.|[2]Suda H, et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo) . 1972 Apr;25 (4) :263-6.|[3]Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63 (6) :768-76.|[4]Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42 (4) :624‐626.|[5]Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74 (9) :3754‐3757.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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