ADRA1D receptor antagonist 1
ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1].
Product Specifications
CAS Number
[1191908-14-1]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/adra1d-receptor-agonist-1.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(Cl)=CN([C@@H](C2=CC=CC(C#N)=C2)C)C1=N)N.[H]Cl
Molecular Formula
C15H14Cl2N4O
Molecular Weight
337.20
References & Citations
[1]Sakauchi N, et al. Discovery of 5-Chloro-1- (5-chloro-2- (methylsulfonyl) benzyl) -2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities. J Med Chem. 2016 Apr 14;59 (7) :2989-3002.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
Available Sizes
Curated Selection
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