RIPK3-IN-1
Product Specifications
UNSPSC Description
RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM[1].
Target Antigen
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk3-in-1.html
Purity
99.19
Solubility
DMSO : 5 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
O=C(C1=CC=CN(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=C4)C(C)=C3C
Molecular Weight
512.53
References & Citations
[1]Amy C Hart, et al. Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage. ACS Med Chem Lett. 2019 May 6;11(3):266-271.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131064/RIPK3-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131064/RIPK3-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2361139-70-8
Available Sizes
Curated Selection
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