SDZ 220-581 (hydrochloride)

SDZ 220-581 hydrochloride is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7[1].

Product Specifications

CAS Number

[179411-93-9]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SDZ-220-581-hydrochloride.html

Purity

99.60

Solubility

DMSO : 5 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=CC=CC=C1C2=CC(C[C@H](N)C(O)=O)=CC(CP(O)(O)=O)=C2.[H]Cl

Molecular Formula

C16H18Cl2NO5P

Molecular Weight

406.20

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Urwyler S, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35 (6) :655-69.|[2]Gilmour G, et al. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39.