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NLRP3/AIM2-IN-2

NLRP3/aim2-in-2 (compound 8) is a new potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent cell death. Its IC 50 value is 0.2392 μ M。

Product Specifications

CAS Number

791840-86-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

AIM2; NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nlrp3-aim2-in-2.html

Purity

99.93

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(O)=C1)CC2=CC=C(OC)C=C2

Molecular Formula

C15H15NO3

Molecular Weight

257.28

Precautions

H302, H315, H319

References & Citations

[1]Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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