NLRP3/AIM2-IN-2
NLRP3/aim2-in-2 (compound 8) is a new potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent cell death. Its IC 50 value is 0.2392 μ M。
Product Specifications
CAS Number
[791840-86-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
AIM2; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-aim2-in-2.html
Purity
99.93
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(O)=C1)CC2=CC=C(OC)C=C2
Molecular Formula
C15H15NO3
Molecular Weight
257.28
Precautions
H302, H315, H319
References & Citations
[1]Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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