MK-886

MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis[1][2][3].

Product Specifications

CAS Number

[118414-82-7]

Product Name Alternative

L 663536

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; FLAP; Leukotriene Receptor; PPAR

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MK-886.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 75 mg/mL (ultrasonic)

Smiles

CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1

Molecular Formula

C27H34ClNO2S

Molecular Weight

472.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR) alpha by MK886. Biochem J. 2001 Jun 15.|[2]Gillard J et al. L-663,536 (MK-886) (3-[1- (4-chlorobenzyl) -3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67 (5) :456-64.