Chaetocin

Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU (VAR) 3-9 with an IC50 of 0.6 μM for SU (VAR) 3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM.

Product Specifications

CAS Number

[28097-03-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Bacterial; Histone Methyltransferase

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Chaetocin.html

Purity

99.58

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@](N1C)(SS2)CO)N3[C@](NC4=CC=CC=C54)([H])[C@]5([C@@]6(C7=CC=CC=C7N8)[C@@]8([H])N(C9=O)[C@](C%10=O)(SS[C@]9(CO)N%10C)C6)C[C@]32C1=O

Molecular Formula

C30H28N6O6S4

Molecular Weight

696.84

Precautions

H302

References & Citations

[1]Greiner D, et al. Identification of a specific inhibitor of the histone methyltransferase SU (VAR) 3-9. Nat Chem Biol. 2005 Aug;1 (3) :143-5.|[2]Tibodeau JD, et al. The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase. Antioxid Redox Signal. 2009 May;11 (5) :1097-106.