GR 94800 (TFA)
GR 94800 TFA is a potent and selective NK2 receptor peptide antagonist, with pKB values of 9.6, 6.4 and 6.0 for NK2, NK1 and NK3 receptors, respectively[1][2].
Product Specifications
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gr-94800-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](CCC1)C(N2[C@@H](CCC2)C(N[C@H](C(N)=O)CCCC)=O)=O)[C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](C)NC([C@H](C)NC(C4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C49H61N9O8·xC2HF3O2
Molecular Weight
904.06 (free base)
References & Citations
[1]A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35 (14) :2582-91.|[2]M A Matuszek, et al. An investigation of tachykinin NK2 receptor subtypes in the rat. Eur J Pharmacol. 1998 Jul 3;352 (1) :103-9.|[3]Stephen D Tichenor, et al. Excitatory motor innervation in the canine rectoanal region: role of changing receptor populations. Br J Pharmacol. 2002 Dec;137 (8) :1321-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NK2R
Frequently Asked Questions
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