RS100329 (hydrochloride)

RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia[1][2].

Product Specifications

CAS Number

[1215654-26-4]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/rs100329-hydrochloride.html

Purity

99.57

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C1N(CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2)C(C(C)=CN1)=O.[H]Cl

Molecular Formula

C20H26ClF3N4O3

Molecular Weight

462.89

References & Citations

[1]Conley RK, et, al. The role of alpha (1) -adrenoceptors and 5-HT (1A) receptors in the control of the micturition reflex in male anaesthetized rats. Br J Pharmacol. 2001 May;133 (1) :61-72.|[2]Williams TJ, et, al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127 (1) :252-8.