RS100329 (hydrochloride)
RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia[1][2].
Product Specifications
CAS Number
1215654-26-4
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/rs100329-hydrochloride.html
Purity
99.57
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
O=C1N(CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2)C(C(C)=CN1)=O.[H]Cl
Molecular Formula
C20H26ClF3N4O3
Molecular Weight
462.89
References & Citations
[1]Conley RK, et, al. The role of alpha (1) -adrenoceptors and 5-HT (1A) receptors in the control of the micturition reflex in male anaesthetized rats. Br J Pharmacol. 2001 May;133 (1) :61-72.|[2]Williams TJ, et, al. In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists. Br J Pharmacol. 1999 May;127 (1) :252-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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