Atpenin A5
Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), and is an effective mKATP channel agonist and cardioprotective agent[1].
Product Specifications
CAS Number
[119509-24-9]
UNSPSC
12352005
Hazard Statement
H301, H312, H330, H410
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/atpenin-a5.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C([C@@H](C)C[C@H](C)[C@@H](Cl)CCl)=O)=C(O)C(OC)=C(OC)N1
Molecular Formula
C15H21Cl2NO5
Molecular Weight
366.24
Precautions
H301, H312, H330, H410
References & Citations
[1]Andrew P Wojtovich, et al. The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels. Basic Res Cardiol. 2009 Mar;104 (2) :121-9.|[2]Jiyoung Bae, et al. Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration. Circulation. 2021 May 18;143 (20) :1973-1986.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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