GRP78-IN-3
GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM) [1].
Product Specifications
CAS Number
[2707510-30-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/grp78-in-3.html
Purity
99.88
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(N1)C=CC=C2)N[C@H](C(NC3=NC=CS3)=O)C(C)C
Molecular Formula
C17H18N4O2S
Molecular Weight
342.42
Precautions
H302, H315, H319
References & Citations
[1]Andrew J Ambrose, et al. Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. J Med Chem. 2022 Dec 14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70; HSPA5
Available Sizes
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