NCGC00244536

NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM.

Product Specifications

CAS Number

[2003260-55-5]

Product Name Alternative

KDM4B Inhibitor B3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NCGC00244536.html

Purity

99.70

Solubility

DMSO : 36.67 mg/mL (ultrasonic)

Smiles

O=C(NCCCC1=CC=CC=C1)C2=CC=CC(C3=CC(O)=C4N=CC=CC4=C3)=C2

Molecular Formula

C25H22N2O2

Molecular Weight

382.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Duan L, et al. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol. 2015 Sep 17;22 (9) :1185-96.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

KDM4

Available Sizes

Curated Selection

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