12 (S) -HEPE

12 (S) -HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12 (S) -HEPE to 12 (S),20-diHEPE, whereas stimulated neutrophils produce 5 (S),12 (S) -HEPE via the 5-lipoxygenase pathway. The competitive action of 12 (S) -HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.