(-)-(S)-Equol
Product Specifications
UNSPSC Description
(-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM.
Target Antigen
Endogenous Metabolite; Estrogen Receptor/ERR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_-_-_S_-Equol.html
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic;warming)
Smiles
OC1=CC=C2C[C@H](COC2=C1)C3=CC=C(C=C3)O
Molecular Weight
242.274
References & Citations
[1]Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81(5):1072-9.|[2]Lu Z, et al. S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway. Curr Cancer Drug Targets. 2016;16(5):455-65.|[3]Horiuchi H, et al. S-equol nantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. J Nutr Sci Vitaminol (Tokyo). 2014;60(4):291-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100583/minus-S-Equol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100583/minus-S-Equol-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
531-95-3
Available Sizes
Curated Selection
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