(-) - (S) -Equol
(-) - (S) -Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM.
Product Specifications
CAS Number
531-95-3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite; Estrogen Receptor/ERR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_-_-_S_-Equol.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
OC1=CC=C2C[C@H](COC2=C1)C3=CC=C(C=C3)O
Molecular Formula
C15H14O3
Molecular Weight
242.27
Precautions
H315, H319, H335
References & Citations
[1]Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81 (5) :1072-9.|[2]Lu Z, et al. S-equol, a Secondary Metabolite of Natural Anticancer Isoflavone Daidzein, Inhibits Prostate Cancer Growth In Vitro and In Vivo, Though Activating the Akt/FOXO3a Pathway. Curr Cancer Drug Targets. 2016;16 (5) :455-65.|[3]Horiuchi H, et al. S-equol nantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells. J Nutr Sci Vitaminol (Tokyo) . 2014;60 (4) :291-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
Isoform
Human Endogenous Metabolite
Available Sizes
Frequently Asked Questions
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