Hypotaurine
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant[1].
Product Specifications
CAS Number
300-84-5
Product Name Alternative
2-Aminoethanesulfinic acid
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Hypotaurine.html
Concentration
10mM
Purity
99.98
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
NCCS(O)=O
Molecular Formula
C2H7NO2S
Molecular Weight
109.15
Precautions
H315, H319, H335
References & Citations
[1]Green TR, et al. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim Biophys Acta. 1991 Jan 23;1073 (1) :91-7. https://www.ncbi.nlm.nih.gov/pubmed/1846756|[2]Gao P, et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. Oncotarget. 2016 Mar 22;7 (12) :15200-14.|[3]Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43 (1) :397-404. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43 (1) :397-404.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Available Sizes
Frequently Asked Questions
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