Hypotaurine

Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant[1].

Product Specifications

CAS Number

[300-84-5]

Product Name Alternative

2-Aminoethanesulfinic acid

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Hypotaurine.html

Concentration

10mM

Purity

99.98

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

NCCS(O)=O

Molecular Formula

C2H7NO2S

Molecular Weight

109.15

Precautions

H315, H319, H335

References & Citations

[1]Green TR, et al. Antioxidant role and subcellular location of hypotaurine and taurine in human neutrophils. Biochim Biophys Acta. 1991 Jan 23;1073 (1) :91-7. https://www.ncbi.nlm.nih.gov/pubmed/1846756|[2]Gao P, et al. Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. Oncotarget. 2016 Mar 22;7 (12) :15200-14.|[3]Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43 (1) :397-404. Hara K, et al. Antinociceptive effect of intrathecal administration of hypotaurine in rat models of inflammatory and neuropathic pain. Amino Acids. 2012 Jul;43 (1) :397-404.