CI-1040

CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1.

Product Specifications

CAS Number

[212631-79-3]

Product Name Alternative

PD 184352

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; MEK

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CI-1040.html

Purity

99.91

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3

Molecular Formula

C17H14ClF2IN2O2

Molecular Weight

478.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Allen LF, et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK) . Semin Oncol. 2003 Oct;30 (5 Suppl 16) :105-16.|[2]Wei CR, et al. MEK inhibitor CI-1040 induces apoptosis in acute myeloid leukemia cells in vitro. Eur Rev Med Pharmacol Sci. 2016 May;20 (10) :1961-8.|[3]Kramer BW, et al. Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040strongly reduces growth and improves lung structure. BMC Cancer. 2004 Jun 1;4:24.