ML345
ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC50 value of 188 nM. ML345 can be for use as a pharmacophore for agent development in diabetes research[1].
Product Specifications
CAS Number
1632125-79-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Proteolytic Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ml345.html
Purity
99.37
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C2=C(SN1C3=CC(S(N4CCOCC4)(=O)=O)=CC=C3N5CCOCC5)C=CC(F)=C2
Molecular Formula
C21H22FN3O5S2
Molecular Weight
479.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Bannister TD, et al. ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE) . In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD) : National Center for Biotechnology Information (US) ; December 17, 2012.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY422745 100 µg
Vitamin D Receptor (VDR) (NM_001017535) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNCB0416-500 1x 500 µL
Fascin-1 (FSCN1/416), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 