ML345

ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC50 value of 188 nM. ML345 can be for use as a pharmacophore for agent development in diabetes research[1].

Product Specifications

CAS Number

[1632125-79-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Proteolytic Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ml345.html

Purity

99.37

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C2=C(SN1C3=CC(S(N4CCOCC4)(=O)=O)=CC=C3N5CCOCC5)C=CC(F)=C2

Molecular Formula

C21H22FN3O5S2

Molecular Weight

479.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Bannister TD, et al. ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE) . In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD) : National Center for Biotechnology Information (US) ; December 17, 2012.