ML345
ML345 is a potent and selective insulin-degrading enzyme (IDE) small-molecule inhibitor, with an IC50 value of 188 nM. ML345 can be for use as a pharmacophore for agent development in diabetes research[1].
Product Specifications
CAS Number
[1632125-79-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Proteolytic Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ml345.html
Purity
99.37
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C2=C(SN1C3=CC(S(N4CCOCC4)(=O)=O)=CC=C3N5CCOCC5)C=CC(F)=C2
Molecular Formula
C21H22FN3O5S2
Molecular Weight
479.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Bannister TD, et al. ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE) . In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD) : National Center for Biotechnology Information (US) ; December 17, 2012.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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