Oxolinic acid

Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].

Product Specifications

CAS Number

[14698-29-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Oxolinic-acid.html

Purity

99.10

Solubility

0.5 M NaOH : ≥ 50 mg/mL|DMSO : 1 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(C1=CN(CC)C2=C(C=C3C(OCO3)=C2)C1=O)O

Molecular Formula

C13H11NO5

Molecular Weight

261.23

Precautions

H302

References & Citations

[1]M J Kershaw, et al. The antibacterial and pharmacological activity of oxolinic acid (Prodoxol) . J Antimicrob Chemother. 1975 Sep;1 (3) :311-5.|[2]S H Manes, et al. Inhibition of RNA synthesis by oxolinic acid is unrelated to average DNA supercoiling. J Bacteriol. 1983 Jul; 155 (1) : 420-423.|[3]J Garcia de Mateos-Verchere, et al. Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor. Eur Neuropsychopharmacol. 1998 Dec;8 (4) :255-9.