10Panx
10Panx is a competitive inhibitor of selective Pannexin 1 (PANX1) channels. 10Panx blocks the opening of PANX1 channels, inhibits ATP release and downstream P2X7 receptor-mediated signaling pathways, thereby reducing cell death and inflammatory responses. 10Panx can be used in the study of diseases such as neuropathic pain, inflammatory bowel disease, and Clostridioides difficile infection. 10Panx can effectively reduce mechanical hyperalgesia and enhanced C-reflexes, and inhibit the expression of pro-inflammatory factors such as IL-6[1][2][3].
Product Specifications
CAS Number
955091-53-9
UNSPSC
12352209
Target
Gap Junction Protein
Type
Peptides
Related Pathways
Cytoskeleton
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/10panx.html
Purity
99.48
Solubility
DMSO : 6.67 mg/mL (ultrasonic) |H2O : 11.11 mg/mL (adjust pH to 12 with 1 M NaOH)
Smiles
Molecular Formula
C58H79N15O16
Molecular Weight
1242.34
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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