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10Panx

10Panx is a competitive inhibitor of selective Pannexin 1 (PANX1) channels. 10Panx blocks the opening of PANX1 channels, inhibits ATP release and downstream P2X7 receptor-mediated signaling pathways, thereby reducing cell death and inflammatory responses. 10Panx can be used in the study of diseases such as neuropathic pain, inflammatory bowel disease, and Clostridioides difficile infection. 10Panx can effectively reduce mechanical hyperalgesia and enhanced C-reflexes, and inhibit the expression of pro-inflammatory factors such as IL-6[1][2][3].

Product Specifications

CAS Number

955091-53-9

UNSPSC

12352209

Target

Gap Junction Protein

Type

Peptides

Related Pathways

Cytoskeleton

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/10panx.html

Purity

99.48

Solubility

DMSO : 6.67 mg/mL (ultrasonic) |H2O : 11.11 mg/mL (adjust pH to 12 with 1 M NaOH)

Smiles

OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](N)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C58H79N15O16

Molecular Weight

1242.34

References & Citations

[1]Aresta Branco MSL, et al. The Pannexin 1 Channel and the P2X7 Receptor Are in Complex Interplay to Regulate the Release of Soluble Ectonucleotidases in the Murine Bladder Lamina Propria. Int J Mol Sci. 2023 Jun 9;24 (12) :9964.|[2]Loureiro AV, et al. Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia. Front Immunol. 2022 Aug 22;13:956340.|[3]Bravo D, et al. NMDA and P2X7 Receptors Require Pannexin 1 Activation to Initiate and Maintain Nociceptive Signaling in the Spinal Cord of Neuropathic Rats. Int J Mol Sci. 2022 Jun 16;23 (12) :6705.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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