GTP-14564

GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and FLT3. GTP-14564 inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells[1].

Product Specifications

CAS Number

[34823-86-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

FLT3

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gtp-14564.html

Purity

99.91

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=C(NN=C2C3=CC=CC=C3)C4=CC=CC=C4O1

Molecular Formula

C15H10N2O

Molecular Weight

234.25

Precautions

H302, H315, H319

References & Citations

[1]Murata K, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3) . J Biol Chem. 2003 Aug 29;278 (35) :32892-8.