Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Etamicastat (hydrochloride)

Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2].

Product Specifications

CAS Number

677773-32-9

Product Name Alternative

BIA 5-453 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H319

Target

Dopamine β-hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/etamicastat-hydrochloride.html

Purity

98.14

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

FC1=CC(F)=C2OC[C@@H](CC2=C1)N3C(CCN)=CNC3=S.[H]Cl

Molecular Formula

C14H16ClF2N3OS

Molecular Weight

347.81

Precautions

P264-P280-P305+P351+P338

References & Citations

[1]Loureiro AI, et al. Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat. Eur J Pharmacol. 2014 Oct 5;740:285-94.|[2]ManuelVaz-da-Silva, et al. Cardiac safety profile of etamicastat, a novel peripheral selective dopamine-β-hydroxylase inhibitor in non-human primates, human young and elderly healthy volunteers and hypertensive patients. IJC Metabolic & Endocrine. 2015 Jun; (7) : 10-24

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CD105 (ENG) Rabbit Polyclonal Antibody
TA364706 100 µL

CD105 (ENG) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
AKT1 Mouse Monoclonal Antibody [Clone ID: 3A3]
AM06526SU-N 100 µL

AKT1 Mouse Monoclonal Antibody [Clone ID: 3A3]

Sign In for Pricing
View Details
Tissue FFPE Sections, Lung
CS806802 5x 5 µm

Tissue FFPE Sections, Lung

Sign In for Pricing
View Details
Recombinant Human ACE2 Protein (Sumo Tag)
PDEH100506-01 20 µg

Recombinant Human ACE2 Protein (Sumo Tag)

Sign In for Pricing
View Details
Recombinant Human ACE2 Protein (Sumo Tag)
PDEH100506-02 100 µg

Recombinant Human ACE2 Protein (Sumo Tag)

Sign In for Pricing
View Details
Recombinant Human ACE2 Protein (Sumo Tag)
PDEH100506-03 500 µg

Recombinant Human ACE2 Protein (Sumo Tag)

Sign In for Pricing
View Details