Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Etamicastat (hydrochloride)

Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2].

Product Specifications

CAS Number

677773-32-9

Product Name Alternative

BIA 5-453 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H319

Target

Dopamine β-hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/etamicastat-hydrochloride.html

Purity

98.14

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

FC1=CC(F)=C2OC[C@@H](CC2=C1)N3C(CCN)=CNC3=S.[H]Cl

Molecular Formula

C14H16ClF2N3OS

Molecular Weight

347.81

Precautions

P264-P280-P305+P351+P338

References & Citations

[1]Loureiro AI, et al. Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat. Eur J Pharmacol. 2014 Oct 5;740:285-94.|[2]ManuelVaz-da-Silva, et al. Cardiac safety profile of etamicastat, a novel peripheral selective dopamine-β-hydroxylase inhibitor in non-human primates, human young and elderly healthy volunteers and hypertensive patients. IJC Metabolic & Endocrine. 2015 Jun; (7) : 10-24

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Tissue FFPE Sections, Lung
CS806058 5x 5 µm

Tissue FFPE Sections, Lung

Sign In for Pricing
View Details
VILIP1 (VSNL1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2D8]
TA802260BM 100 µL

VILIP1 (VSNL1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2D8]

Sign In for Pricing
View Details
Mouse Fcgrt activation kit by CRISPRa
GA201377 1 Kit

Mouse Fcgrt activation kit by CRISPRa

Sign In for Pricing
View Details
Human IL21 activation kit by CRISPRa
GA111809 1 Kit

Human IL21 activation kit by CRISPRa

Sign In for Pricing
View Details
PRR23C Human Gene Knockout Kit (CRISPR)
KN425352 1 Kit

PRR23C Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
EGFR Mouse Monoclonal Antibody [Clone ID: OTI2F5]
CF806824 100 µg

EGFR Mouse Monoclonal Antibody [Clone ID: OTI2F5]

Sign In for Pricing
View Details