Ac-LEHD-AMC

Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm) . Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity[1].

Product Specifications

CAS Number

[292633-16-0]

UNSPSC

12171500

Target

Caspase

Type

Dye Reagents

Related Pathways

Apoptosis

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ac-lehd-amc.html

Purity

98.96

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)CC2=CN=CN2)=O)=O)C=C1O3)=CC3=O

Molecular Formula

C33H41N7O11

Molecular Weight

711.72

References & Citations

[1]Igor M Prudnikov, et al. Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases. J Biochem. 2012 Mar;151 (3) :299-316.