S26131
S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist[1].
Product Specifications
CAS Number
[296280-56-3]
UNSPSC
12352005
Target
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s26131.html
Concentration
10mM
Purity
99.63
Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(NCCC1=C2C=C(C=CC2=CC=C1)OCCCOC3=CC=C4C=CC=C(C4=C3)CCNC(C)=O)=O
Molecular Formula
C31H34N2O4
Molecular Weight
498.61
References & Citations
[1]Descamps-François C, et al. Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands. J Med Chem. 2003 Mar 27;46 (7) :1127-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MT1
Available Sizes
Curated Selection
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