Pioglitazone (hydrochloride) (Standard)

Pioglitazone (hydrochloride) (Standard) is the analytical standard of Pioglitazone (hydrochloride) . This product is intended for research and analytical applications. Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.

Product Specifications

CAS Number

[112529-15-4]

Product Name Alternative

U 72107A (Standard) ; AD 4833 (Standard)

UNSPSC

12352005

Hazard Statement

H302-H351

Target

Ferroptosis; PPAR; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pioglitazone-hydrochloride-standard.html

Purity

99.89

Smiles

CCC1=CN=C(CCOC2=CC=C(CC3C(NC(S3)=O)=O)C=C2)C=C1.Cl

Molecular Formula

C19H21ClN2O3S

Molecular Weight

392.90

Precautions

P264-P270-P280-P405-P501

References & Citations

[1]Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2- (4-methylphenyl) -4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve|[2]Puddu A, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177 (1-3) :79-84.|[3]Kubota N, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281 (13) :8748-55.|[4]Elrashidy RA, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17 (3) :324-33.