A 419259
A 419259 is a broad-spectrum pyrrolo-pyrimidine inhibitor, has high selectivity towards the Src family. A 419259 shows inhibitory effect for Src, Lck and Lyn with IC50 of 9 nM, [1][2].
Product Specifications
CAS Number
364042-47-7
Product Name Alternative
RK-20449
UNSPSC
12352005
Target
Apoptosis; Src
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-419259.html
Concentration
10mM
Purity
99.75
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1
Molecular Formula
C29H34N6O
Molecular Weight
482.63
References & Citations
[1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21 (53) :8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13 (3 Pt A) :379-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Blood. 2016 Jun 23;127 (25) :3237-52.|Free University of Berlin. 2025 Aug 4.|J Med Chem. 2024 Nov 28;67 (22) :20571-20579.|Microb Pathog. 2024 Dec 25:199:107252.|Patent. US20170333436A1.|Patent. US20250228856A1.|Adv Sci (Weinh) . 2025 Jun 30:e17764.
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