CCR2-RA-[R]
CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.
Product Specifications
CAS Number
512177-83-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/CCR2-RA--R-.html
Purity
99.71
Solubility
DMSO : 37.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(O)=C(C(C)=O)[C@@H](C2CCCCC2)N1C(C(F)=C3)=CC=C3Cl
Molecular Formula
C18H19ClFNO3
Molecular Weight
351.80
Precautions
H315, H319, H335
References & Citations
[1]Zweemer AJ, et al. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Mol Pharmacol. 2013 Oct;84 (4) :551-61.|[2]Zweemer AJ, et al. Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2. Mol Pharmacol. 2014 Oct;86 (4) :358-68.|[3]Zheng Y, et al. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 Dec 15;540 (7633) :458-461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2
Available Sizes
Frequently Asked Questions
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