CCR2-RA-[R]

CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.

Product Specifications

CAS Number

[512177-83-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/CCR2-RA--R-.html

Purity

99.71

Solubility

DMSO : 37.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C(O)=C(C(C)=O)[C@@H](C2CCCCC2)N1C(C(F)=C3)=CC=C3Cl

Molecular Formula

C18H19ClFNO3

Molecular Weight

351.80

Precautions

H315, H319, H335

References & Citations

[1]Zweemer AJ, et al. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Mol Pharmacol. 2013 Oct;84 (4) :551-61.|[2]Zweemer AJ, et al. Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2. Mol Pharmacol. 2014 Oct;86 (4) :358-68.|[3]Zheng Y, et al. Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 Dec 15;540 (7633) :458-461.