WWL113

WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases) [1].

Product Specifications

CAS Number

[947669-86-5]

UNSPSC

12352005

Target

Carboxylesterase (CES)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/wwl113.html

Purity

99.72

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(CC1=CC(C2=CC=NC=C2)=CC=C1)C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O

Molecular Formula

C29H26N2O4

Molecular Weight

466.53

References & Citations

[1]Dominguez, E., Galmozzi, A., Chang, J.W., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat. Chem. Biol. 10 (2), 113-121 (2014) .|[2]Galmozzi, et al. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Rep. 2014 Dec 11;9 (5) :1584-1593.|[3]Turcotte C, et al. The Endocannabinoid Metabolite Prostaglandin E2 (PGE2) -Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors. J Immunol. 2017 Apr 15;198 (8) :3255-3263.