WWL113
WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases) [1].
Product Specifications
CAS Number
947669-86-5
UNSPSC
12352005
Target
Carboxylesterase (CES)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/wwl113.html
Purity
99.72
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN(CC1=CC(C2=CC=NC=C2)=CC=C1)C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O
Molecular Formula
C29H26N2O4
Molecular Weight
466.53
References & Citations
[1]Dominguez, E., Galmozzi, A., Chang, J.W., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat. Chem. Biol. 10 (2), 113-121 (2014) .|[2]Galmozzi, et al. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Rep. 2014 Dec 11;9 (5) :1584-1593.|[3]Turcotte C, et al. The Endocannabinoid Metabolite Prostaglandin E2 (PGE2) -Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors. J Immunol. 2017 Apr 15;198 (8) :3255-3263.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CES1; CES3
Available Sizes
Frequently Asked Questions
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