Mal-PEG1-Val-Cit-PABC-OH
Mal-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[2055041-37-5]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-peg1-val-cit-pabc-oh.html
Purity
95.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC(C=C1)=CC=C1CO)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCN(C2=O)C(C=C2)=O)=O)=O
Molecular Formula
C27H38N6O8
Molecular Weight
574.63
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Protease Cleavable Linker
Available Sizes
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