Nexopamil
Nexopamil is a calcium antagonist of Ca2+ channel, 5HT2, 5HT1A, 5HT1C and dopamine D2 receptors. Nexopamil exhibits vasodilatory, cardioprotective, and platelet aggregation inhibiting effects. Nexopamil can be used for researches of stable or unstable angina and possibly of peripheral arterial occlusive disease[1].
Product Specifications
CAS Number
136033-49-3
UNSPSC
12352005
Target
5-HT Receptor; Calcium Channel; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nexopamil.html
Solubility
10 mM in DMSO
Smiles
CCCCCCN(C)CCC[C@@](C#N)(C1=CC(OC)=C(OC)C(OC)=C1)C(C)C
Molecular Formula
C24H40N2O3
Molecular Weight
404.59
References & Citations
[1]Michael K, et al. Nexopamil (LU 49938), A Combined Ca2+ Channel Blocker and 5HT2 Receptor Antagonist. Cardiovascular Drug Reviews. Sep 1994
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT1 Receptor
Available Sizes
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