MT477
Product Specifications
UNSPSC Description
MT477 is a potent protein kinase C (PKC) inhibitor. MT477 induces apoptosis and necrosis. MT477 decreases the protein expression of Ras-GTP, p-Erk1/2, p-Elk1. MT477 shows antitumor activity[1].
Target Antigen
PKC
Type
Reference compound
Related Pathways
Epigenetics;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mt477.html
Smiles
O=C(OC)C1=C(SC2=C(C3=C(C(OC)=CC=C3)N(C2(C)C)C(CN4C(CCC4=O)=O)=O)C15SC(C(OC)=O)=C(S5)C(OC)=O)C(OC)=O
Molecular Weight
718.77
References & Citations
[1]Jasinski P, et al. A novel quinoline, MT477: suppresses cell signaling through Ras molecular pathway, inhibits PKC activity, and demonstrates in vivo anti-tumor activity against human carcinoma cell lines. Invest New Drugs. 2008 Jun;26(3):223-32.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122241/MT477-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122241/
Clinical Information
No Development Reported
CAS Number
328069-91-6
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
FAB9926I 0.1 mL
Human Monoclonal CD25/IL-2R alpha Antibody (Hu107) [Janelia Fluor 549]
Ask
View Details