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Sucrosofate (potassium)

Sucrosofate (Sucrose octasulfate) potassium is a sucrose acid that can be used to prepare liposomes to deliver Irinotecan (HY-16562) . Irinotecan is an inhibitor of topoisomerase Topo I and is commonly used in colon and rectal cancer research. Sucrosofate nanoliposome preparation loaded with Irinotecan, also known as PEP02 or MM-398[1][2].

Product Specifications

CAS Number

[73264-44-5]

Product Name Alternative

Sucrose octasulfate (potassium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sucrosofate-potassium.html

Purity

98.0

Solubility

H2O : 175 mg/mL (ultrasonic)

Smiles

O=S(OC[C@@]1([C@H]([C@@H]([C@H](O1)COS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)COS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)OS(=O)(O[K])=O)(O[K])=O

Molecular Formula

C12H14K8O35S8

Molecular Weight

1287.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Ko A H, Tempero M A, Shan Y S, et al. A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer[J]. British journal of cancer, 2013, 109 (4) : 920-925.|[2]Klinz S G, Zheng J, De Souza R, et al. Abstract C293: Irinotecan sucrosofate liposome injection, MM-398, demonstrates superior activity and control of hypoxia as measured through longitudinal imaging using [18F] FAZA PET compared to free irinotecan in a colon adenocarcinoma xenograft model[J]. Molecular Cancer Therapeutics, 2013, 12 (11_Supplement) : C293-C293.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-141436/Sucrosofate-potassium-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-141436/Sucrosofate-potassium-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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