PD184161
PD184161 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior[1][2].
Product Specifications
CAS Number
212631-67-9
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Apoptosis; MEK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pd184161.html
Purity
98.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NOCC1CC1)C2=CC(Br)=C(F)C(F)=C2NC(C(Cl)=C3)=CC=C3I
Molecular Formula
C17H13BrClF2IN2O2
Molecular Weight
557.56
Precautions
H315, H319
References & Citations
[1]Klein PJ, et al. The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer. Neoplasia. 2006 Jan;8 (1) :1-8.|[2]Gladbach A, et al. ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke. J Neural Transm (Vienna) . 2014 May;121 (5) :543-7.|[3]Duman CH, et al. A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment. Biol Psychiatry. 2007 Mar 1;61 (5) :661-70.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
500536 25 µg
VEGF, Recombinant, Human (Vascular Endothelial Growth Factor A, VEGF-A, Vascular Permeability Factor, VPF, Vascular Endothelial Growth Factor 165AA, 121aa, VEGFA) discontinued
Sign In for Pricing
View Details MBS1205011-01 0.02 mg (E-Coli)
Recombinant Thermococcus onnurineus Pyridoxal biosynthesis lyase pdxS (pdxS)
Sign In for Pricing
View Details MBS1205011-02 0.02 mg (Yeast)
Recombinant Thermococcus onnurineus Pyridoxal biosynthesis lyase pdxS (pdxS)
Sign In for Pricing
View Details MBS1205011-03 0.1 mg (E-Coli)
Recombinant Thermococcus onnurineus Pyridoxal biosynthesis lyase pdxS (pdxS)
Sign In for Pricing
View Details