DHFR-IN-19
Product Specifications
UNSPSC Description
DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with Ki of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC50 of 14.5 μM[1].
Target Antigen
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dhfr-in-19.html
Smiles
NC(NC1=NC2=CC(C)=C(C)C=C2N1)=N
Molecular Weight
203.24
References & Citations
[1]Francesconi V, et al., Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents. ACS Infect Dis. 2024 Jul 2.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162656/DHFR-IN-19-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162656/
Clinical Information
No Development Reported
CAS Number
41927-06-4
Curated Selection
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