DHFR-IN-19

DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with Ki of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC50 of 14.5 μM[1].

Product Specifications

CAS Number

[41927-06-4]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-19.html

Smiles

NC(NC1=NC2=CC(C)=C(C)C=C2N1)=N

Molecular Formula

C10H13N5

Molecular Weight

203.24

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Francesconi V, et al., Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents. ACS Infect Dis. 2024 Jul 2.